Protein name:
Collagenase 3 ;
Alternative:
Matrix metalloproteinase-13 (MMP-13) ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MHPGVLAAFL | FLSWTHCRAL | PLPSGGDEDD | LSEEDLQFAE | RYLRSYYHPT |
100:
NLAGILKENA | ASSMTERLRE | MQSFFGLEVT | GKLDDNTLDV | MKKPRCGVPD |
150:
VGEYNVFPRT | LKWSKMNLTY | RIVNYTPDMT | HSEVEKAFKK | AFKVWSDVTP |
200:
LNFTRLHDGI | ADIMISFGIK | EHGDFYPFDG | PSGLLAHAFP | PGPNYGGDAH |
250:
FDDDETWTSS | SKGYNLFLVA | AHEFGHSLGL | DHSKDPGALM | FPIYTYTGKS |
300:
HFMLPDDDVQ | GIQSLYGPGD | EDPNPKHPKT | PDKCDPSLSL | DAITSLRGET |
350:
MIFKDRFFWR | LHPQQVDAEL | FLTKSFWPEL | PNRIDAAYEH | PSHDLIFIFR |
400:
GRKFWALNGY | DILEGYPKKI | SELGLPKEVK | KISAAVHFED | TGKTLLFSGN |
450:
QVWRYDDTNH | IMDKDYPRLI | EEDFPGIGDK | VDAVYEKNGY | IYFFNGPIQF |
471:
EYSIWSNRIV | RVMPANSILW | C
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Rabbit
Bovine
ELISA Kit for Human Collagenase 3
ELISA Kit for Human Collagenase 3
ELISA Kit for Human Collagenase 3
ELISA Kit for Human Collagenase 3
ELISA Kit for Human Collagenase 3
CLIA Kit for Human Collagenase 3
CLIA Kit for Human Collagenase 3
CLIA Kit for Human Collagenase 3
CLIA Kit for Human Collagenase 3
CLIA Kit for Human Collagenase 3
Polyclonal Antibody for Human Collagenase 3
Polyclonal Antibody for Human Collagenase 3
Polyclonal Antibody for Human Collagenase 3
Polyclonal Antibody for Human Collagenase 3
Polyclonal Antibody for Human Collagenase 3
Monoclonal Antibody for Human Collagenase 3
Monoclonal Antibody for Human Collagenase 3
Monoclonal Antibody for Human Collagenase 3
Monoclonal Antibody for Human Collagenase 3
Monoclonal Antibody for Human Collagenase 3
Protein for Human Collagenase 3
Protein for Human Collagenase 3
Protein for Human Collagenase 3
Protein for Human Collagenase 3
Protein for Human Collagenase 3
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Citations
[1].
G Han, H Shao, X Zhu, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];CATALYTIC ACTIVITY;FUNCTION;TISSUE SPECIFICITY
tissue :
Mammary carcinoma .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
3.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Esophagus .
tissue :
Synovium .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLY-390
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 20-27 AND 104-118;PROPEPTIDE;AUTOCATALYTIC PROCESSING;CATALYTIC ACTIVITY;FUNCTION;GLYCOSYLATION AT ASN-117;SUBCELLULAR LOCATION;ENZYME REGULATION;INTERACTION WITH TIMP1; TIMP2 AND TIMP3
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE;PROPEPTIDE;FUNCTION;CATALYTIC ACTIVITY
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION;TISSUE SPECIFICITY
10.
"Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development."
Johansson N.
,
Saarialho-Kere U.
,
Airola K.
,
Herva R.
,
Nissinen L.
,
Westermarck J.
,
Vuorio E.
,
Heino J.
,
Kaehaeri V.M.
Dev. Dyn.208:387-397(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;INDUCTION BY TGFB1
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DOMAIN;CATALYTIC ACTIVITY;AUTOCATALYTIC PROCESSING;FUNCTION;INTERACTION WITH TIMP1; TIMP2 AND TIMP3;ENZYME REGULATION
12.
"A secreted tyrosine kinase acts in the extracellular environment."
Bordoli M.R.
,
Yum J.
,
Breitkopf S.B.
,
Thon J.N.
,
Italiano J.E. Jr.
,
Xiao J.
,
Worby C.
,
Wong S.K.
,
Lin G.
,
Edenius M.
,
Keller T.L.
,
Asara J.M.
,
Dixon J.E.
,
Yeo C.Y.
,
Whitman M.
Cell158:1033-1044(2014)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-366
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 265-471 IN COMPLEX WITH CALCIUM;DISULFIDE BOND
14.
"Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors."
Lovejoy B.
,
Welch A.R.
,
Carr S.
,
Luong C.
,
Broka C.
,
Hendricks R.T.
,
Campbell J.A.
,
Walker K.A.
,
Martin R.
,
Van Wart H.
,
Browner M.F.
Nat. Struct. Biol.6:217-221(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 104-271 IN COMPLEXES WITH SYNTHETIC INHIBITORS; CALCIUM AND ZINC;PROPEPTIDE;AUTOCATALYTIC PROCESSING
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 104-274 IN COMPLEX WITH CALCIUM AND ZINC
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 104-268 IN COMPLEX WITH CALCIUM AND ZINC;CATALYTIC ACTIVITY
17.
"Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14."
Blagg J.A.
,
Noe M.C.
,
Wolf-Gouveia L.A.
,
Reiter L.A.
,
Laird E.R.
,
Chang S.P.
,
Danley D.E.
,
Downs J.T.
,
Elliott N.C.
,
Eskra J.D.
,
Griffiths R.J.
,
Hardink J.R.
,
Haugeto A.I.
,
Jones C.S.
,
Liras J.L.
,
Lopresti-Morrow L.L.
,
Mitchell P.G.
,
Pandit J.
,
Robinson R.P.
,
Subramanyam C.
,
Vaughn-Bowser M.L.
,
Yocum S.A.
more...
Bioorg. Med. Chem. Lett.15:1807-1810(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 104-271 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 104-274 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY
19.
"Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects."
Johnson A.R.
,
Pavlovsky A.G.
,
Ortwine D.F.
,
Prior F.
,
Man C.F.
,
Bornemeier D.A.
,
Banotai C.A.
,
Mueller W.T.
,
McConnell P.
,
Yan C.
,
Baragi V.
,
Lesch C.
,
Roark W.H.
,
Wilson M.
,
Datta K.
,
Guzman R.
,
Han H.K.
,
Dyer R.D.
J. Biol. Chem.282:27781-27791(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 104-270 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY;FUNCTION IN CARTILAGE DEGRADATION
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 104-268 IN COMPLEX WITH TIMP2; CALCIUM AND ZINC;INTERACTION WITH TIMP2
21.
"Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13."
Monovich L.G.
,
Tommasi R.A.
,
Fujimoto R.A.
,
Blancuzzi V.
,
Clark K.
,
Cornell W.D.
,
Doti R.
,
Doughty J.
,
Fang J.
,
Farley D.
,
Fitt J.
,
Ganu V.
,
Goldberg R.
,
Goldstein R.
,
Lavoie S.
,
Kulathila R.
,
Macchia W.
,
Parker D.T.
,
Melton R.
,
O'Byrne E.
,
Pastor G.
,
Pellas T.
,
Quadros E.
,
Reel N.
,
Roland D.M.
,
Sakane Y.
,
Singh H.
,
Skiles J.
,
Somers J.
,
Toscano K.
,
Wigg A.
,
Zhou S.
,
Zhu L.
,
Shieh W.C.
,
Xue S.
,
McQuire L.W.
more...
J. Med. Chem.52:3523-3538(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 104-274 IN COMPLEX WITH CALCIUM AND ZINC;CATALYTIC ACTIVITY;COFACTOR;FUNCTION
22.
"Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis."
Schnute M.E.
,
O'Brien P.M.
,
Nahra J.
,
Morris M.
,
Howard Roark W.
,
Hanau C.E.
,
Ruminski P.G.
,
Scholten J.A.
,
Fletcher T.R.
,
Hamper B.C.
,
Carroll J.N.
,
Patt W.C.
,
Shieh H.S.
,
Collins B.
,
Pavlovsky A.G.
,
Palmquist K.E.
,
Aston K.W.
,
Hitchcock J.
,
Rogers M.D.
,
McDonald J.
,
Johnson A.R.
,
Munie G.E.
,
Wittwer A.J.
,
Man C.F.
,
Settle S.L.
,
Nemirovskiy O.
,
Vickery L.E.
,
Agawal A.
,
Dyer R.D.
,
Sunyer T.
more...
Bioorg. Med. Chem. Lett.20:576-580(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 104-270 IN COMPLEX WITH CALCIUM AND ZINC;CATALYTIC ACTIVITY;COFACTOR
23.
"Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease."
Becker D.P.
,
Barta T.E.
,
Bedell L.J.
,
Boehm T.L.
,
Bond B.R.
,
Carroll J.
,
Carron C.P.
,
Decrescenzo G.A.
,
Easton A.M.
,
Freskos J.N.
,
Funckes-Shippy C.L.
,
Heron M.
,
Hockerman S.
,
Howard C.P.
,
Kiefer J.R.
,
Li M.H.
,
Mathis K.J.
,
McDonald J.J.
,
Mehta P.P.
,
Munie G.E.
,
Sunyer T.
,
Swearingen C.A.
,
Villamil C.I.
,
Welsch D.
,
Williams J.M.
,
Yu Y.
,
Yao J.
more...
J. Med. Chem.53:6653-6680(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 104-267 IN COMPLEX WITH CALCIUM AND ZINC;CATALYTIC ACTIVITY;COFACTOR;FUNCTION
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.43 ANGSTROMS) OF 104-272 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY;ENZYME REGULATION;FUNCTION
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS) OF 103-274 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;CATALYTIC ACTIVITY;FUNCTION
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 104-471 OF MUTANT ALA-223 IN COMPLEX WITH CALCIUM AND ZINC;COFACTOR;DISULFIDE BOND;MUTAGENESIS OF GLU-223;ACTIVE SITE;SUBUNIT
27.
"MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMD(MO)."
Kennedy A.M.
,
Inada M.
,
Krane S.M.
,
Christie P.T.
,
Harding B.
,
Lopez-Otin C.
,
Sanchez L.M.
,
Pannett A.A.J.
,
Dearlove A.
,
Hartley C.
,
Byrne M.H.
,
Reed A.A.C.
,
Nesbit M.A.
,
Whyte M.P.
,
Thakker R.V.
J. Clin. Invest.115:2832-2842(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SEMD-MO SER-75;CHARACTERIZATION OF VARIANT SEMD-MO SER-75;FUNCTION IN BONE DEVELOPMENT
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS MANDP1 SER-74; THR-91 AND ASN-232;FUNCTION IN BONE DEVELOPMENT